The correct answer is B.

The nurse cares for a client diagnosed with gout. The nurse instructs the client about allopurinol (Zyloprim). Which statement by the client indicates to the nurse the need for further instruction?

  • 1. "It will take at least 2 to 3 weeks for my gout symptoms to improve. "
  • 2. "It will be necessary for me to decrease my fluid intake now."
  • 3. "I should take the medication with meals to decrease upset stomach."
  • 4. "This medication increases the excretion of uric acid through the kidneys."


  • 1. It takes approximately 2 to 3 weeks for serum uric acid levels to return to normal limits after allopurinol therapy is initiated.
  • 2. CORRECT - When taking allopurinol, the client should consume enough fluids to maintain a urine output of at least 2 liters per day; will prevent formation of uric acid kidney stones.
  • 3. Allopurinol should be taken with or immediately after meals to decrease gastric irritation.
  • 4. Allopurinol decreases the formation of uric acid by blocking the enzyme necessary for uric acid formation. Allopurinol is used to treat chronic gout and will decrease the size of tophi and prevents formation of new tophi.

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